pentobarbital will decrease the extent or outcome of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Solid or average CYP3A4 inducers may possibly enhance charge of diazepam elimination; therefore, efficacy of diazepam could possibly be decreased.
Check Closely (one)pentobarbital will boost the amount or influence of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Remark: Barbiturates might maximize adverse effects, such as respiratory melancholy, made by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.
fentanyl intranasal and pentobarbital each improve sedation. Stay away from or Use Alternate Drug. Limit use to individuals for whom different remedy selections are inadequate
pentobarbital will reduce the level or result of levamlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the extent or influence of irinotecan liposomal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Possibly increases toxicity of another by pharmacodynamic synergism. Prevent or Use Alternate Drug. Profound sedation, respiratory despair, coma, and death may final result if coadministered. Reserve concomitant prescribing of such drugs in clients for whom other treatment alternatives are inadequate. Limit dosages and durations to the minimum required. check here Keep track of closely for indications of respiratory despair and sedation.
pentobarbital will lower the extent or result of montelukast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.
pentobarbital will lessen the extent or impact of zolpidem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.
pentobarbital will decrease the level or influence of cevimeline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.
pentobarbital will reduce the extent or influence of cinacalcet by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Hypnotic doses of these barbiturates tend not to surface to considerably impair uterine exercise during labor; total anesthetic doses of barbiturates minimize the power and frequency of uterine contractions; administration of sedative-hypnotic barbiturates towards the mom in the course of labor may lead to respiratory melancholy inside the new child
pentobarbital will decrease the level or effect of etravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will decrease the extent or effect of doxorubicin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.